The Nikkei 225 fell 0.6% to close at 66019.90 points, primarily dragged down by electronics, machinery, and automotive stocks. Investors remained concerned about uncertainties surrounding the Middle East conflict and the Federal Reserve's policies. Among individual stocks, Murata Manufacturing dropped 4.1%, Mitsubishi Heavy Industries declined 2.5%, and Toyota Motor fell 2.3%. The dollar-yen exchange rate was 153.80 yen, lower than 155.69 yen at Monday's close in Tokyo.