Bitcoin and Ethereum both gained about 7% in September, with Bitcoin ending the month around $83,000-$84,000 and Ethereum around $2,650-$2,700. U.S. spot Bitcoin ETFs attracted $2.4 billion in the week ending September 25, marking their strongest weekly inflow since October 2025. U.S. spot XRP ETFs recorded 11 consecutive weeks of inflows, with cumulative inflows of $1.79 billion by September 25.

Key catalysts for October include Ethereum's Glamsterdam upgrade testing, with its first public testnet scheduled for October 6, continued ETF demand, and developments around XRP Ledger upgrades. Fidelity Investments' global macro director Jurrien Timmer has presented a model-based scenario in which Bitcoin could reach $300,000 by 2029, assuming it maintains long-term support around $60,000.