In an October 2 podcast interview, Seema Amble, a partner at a16z, and Vladimir Keil, CEO of Lio, a startup specializing in enterprise AI procurement agents, noted that traditional software giants are constrained by existing system boundaries and internal conflicts of interest, making it difficult for them to advance autonomous AI agents. This presents a core opportunity for AI-native startups. Keil stated that approximately 80% of enterprise procurement occurs outside ERP systems, and AI agents can handle procurements under $50,000 that traditional enterprises overlook due to human resource limitations. Achieving a 1% reduction in procurement costs can yield a profit effect equivalent to a 10% increase in revenue. Both emphasized that winning the market hinges on owning "end-to-end processes" rather than merely embedding chatbots into existing workflows, and that human-AI collaboration is essential for building trust and a competitive moat.